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Sativa strains are a subspecies of the cannabis plant that are commonly recommended for daytime use due to their uplifting and energizing effects. They are known to produce a cerebral or head-high, which enhances creativity and productivity. Sativa plants are taller with thinner leaves compared to Indica plants, which are shorter and bushier. The chemical composition of Sativa strains produces high levels of THC, which is the psychoactive compound that induces the "high" associated with cannabis use. On the other hand, CBD is non-euphoric and produces physical benefits such as reducing pain and nausea. Sativa strains tend to have a higher THC to CBD ratio, unlike Indica strains which produce more CBD than THC. The difference in aroma between Sativa and Indica strains is a result of terpenes, which can also influence the effects of specific strains.

